Below is the lecture schedule. All lectures are in 153 Noyes starting at 2:30 pm, except where noted. The lecture topics/lecturer is subject to change, but the dates and times are set. Some lectures have required readings that must be done before lecture. PDFs of the reading material are linked to in the schedule and will be updated as the term progresses. Those marked with an asterisk require a reading memo.
Scheduled office hours for the TAs to help you with your homework are 3:00-4:30 pm on Mondays in Spalding 106 (except Feb. 5, in 229 SFL).
Due dates
- Tu 01/30: Homework 1 due
- Tu 02/13: Homework 2 due
- Tu 02/27: Homework 3 due
- Tu 03/13: Homework 4 due
- Fr 03/16: News and Views due at 5 PM
Lecture Schedule
- L1: Th 01/04: (JB) Overview of biomolecular design
- L2: Tu 01/09: (NP)
- Cameron, Bashor, Collins, 2014 (optional)
- Huang, Boyken, Baker, 2016 (optional)
- Pinheiro, et al., 2011 (optional)
- Zhang and Seelig, 2011 (optional)
- L3: Th 01/11: (NP)
- L4: Tu 01/16: (NP) lecture in 106 Spalding
- L5: Th 01/18: (NP)
- L6: Tu 01/23: (NP) lecture in 147 Noyes
- L7: Th 01/25: (NP)
- L8: Tu 01/30: (NP)
- L9: Th 02/01: (NP)
- L10: Tu 02/06: (NP)
- L11: Th 02/08: (JB) Evolution as a search in sequence space
- L12: Tu 02/13: (JB) Introduction to directed evolution
- Arnold, 2017 (may be postponed)
- Glasner, et al., 2007 (may be postponed)
- *Romero and Arnold, 2009
- Drummond, et al., 2005 (may be postponed)
- L13: Th 02/15: (JB) The tale of cytochome P450
- L14: Tu 02/20: (KY) The nuts and bolts of directed evolution
- L15: Th 02/22: (JB) Sex in the test tube
- L16: Tu 02/27: (JB) Introduction to Gaussian processes (lecture notes)
- L17: Th 03/01: (JB) Probing fitness landscapes with Gaussian processes
- L18: Tu 03/06: (JB) Probabilistic engineering
- L19: Th 03/08: Special guest lecture from Possu Huang